A serendipitous milestone in respiratory neurobiology.
نویسنده
چکیده
Throughout the history of science, explaining the origins of breathing has been one of the holy grails of animal physiology. During the antiquity, Galen of Pergamon noted that gladiators and animals injured below the neck continued to breathe whereas those injured in the neck stopped. With time, more precise transection experiments narrowed down the brain areas necessary for breathing and in 1858, the French biologist Pierre Flourens coined the evocative term ‘noeud vital’ to refer to the brainstem structures that regulate and generate breathing (Feldman and McCrimmon, 2003). Yet the specific anatomical and neurophysiological substrates for breathing remained unclear. As is often the case, the development of new experimental approaches allows giant leaps within a specific research area, and the work of Edgar Adrian and Frederik Buytendijk on isolated brainstem of goldfish reported in The Journal of Physiology in 1931 (Adrian and Buytendijk, 1931), unbeknownst to them at the time, represents such a milestone that ultimately led to significant advances in respiratory neurobiology.
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عنوان ژورنال:
- The Journal of experimental biology
دوره 216 Pt 14 شماره
صفحات -
تاریخ انتشار 2013